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New genetic markers could help predict onset of debilitating eye disease

Fuseworks Media
Fuseworks Media

Scientists have discovered 19 new genetic markers that could predict whether a person is at a higher risk of eye disease.

The genome-wide study of 25,000 people almost doubles the number of known genetic variants for that affect how thick the cornea is and brings the total number of known variants to 45.

The findings were published today in Nature Communications.

The head of QIMR Berghofer Medical Research Institute’s Statistical Genetics laboratory, Associate Professor Stuart MacGregor, said corneal thickness was associated with a debilitating condition called keratoconus, that that affected the front surface of the eye.

"This extra information about the genetic basis of the variation in corneal thickness, which is a major risk factor for eye diseases like keratoconus, will help us to better screen for this debilitating condition in the future," he said.

Keratoconus results in a thinning of the cornea, which causes a conical bulge that distorts the vision. In severe cases, sight may only be restored through corneal transplant surgery.

Associate Professor MacGregor said the discovery of new genetic markers could help predict a person’s future risk of corneal thinning.

"Corneal thickness is remarkable because it is one of the most heritable human traits," he said.

"If we mapped more of the genes for corneal thickness, you could predict at birth what a person’s corneal thickness would be with very high accuracy because there are almost no environmental factors that determine it.

"The discovery of additional genetic markers will help us to reliably predict which people are at a higher risk of keratoconus in the future, which is very exciting."

He said the findings also enhanced understanding of the genetics of connective tissue disorders such as Ehlers-Danlos syndrome, Marfan syndrome and brittle corneal syndrome.

"We are finding there is a lot more overlap between what some of these genetic markers do and what was previously thought," he said.

"These discoveries are exciting because they tell us what features could be important in the development of new treatments."

Associate Professor MacGregor said the research did not find an association between low corneal thickness and glaucoma.

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